By Ivana Pantelic
The on-going ‘green’ development within the own care coupled with worldwide environmental issues, position natural-origin, biodegradable and skin-friendly surfactants reminiscent of alkyl polyglucosides (APGs) in excessive call for. After winning use in cosmetics, adequate information has been bought to welcome a few sugar emulsifiers into the sector of drug dosage. Alkyl Polyglucosides provides a accomplished compendium which courses a researcher from the APG-related preformulation phases to formula processing, together with the research of assorted APG-stabilized structures pores and skin functionality. This publication introduces a number of APG representatives, their merits with regards to sure traditional surfactants, physicochemical and interfacial houses, attainable interplay with widespread constituents and numerous characterization suggestions crucial for the review of colloidal platforms. the 1st bankruptcy introduces alkyl polyglucosides, by means of chapters on their houses, behaviour, an outline of the patent defense mechanisms and instructions for filing patent purposes. ultimately, a end surveys foreign patent functions related to APGs.
- introduces the sector of alkyl polyglucoside emulsifiers, directory all of the modern and newly synthesized APG emulsifiers
- provides specified details on a variety of elements of APG-based buildings
- reveals strength of APG-stabilized autos as potential supply platforms utilizing numerous version medicines and beauty actives
- includes an updated assessment of study performed within the box of APGs, facilitating destiny preformulation and formula experiences for researchers
- offers a concise and useful compendium of characterization concepts
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Extra info for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems
Balzer D, Luders H, eds. , 2000. British Pharmacopoeia 2009 (BP 2009), British Pharmacopoeia Commission, The Stationery Office, London: UK, 2009. 48 Behind the Alkyl Polyglucoside-based structures Corrigan OI, Healy AM. Surfactants in pharmaceutical products and systems. In: Swarbrick J, ed. Encyclopedia of pharmaceutical technology. , 2002. Deutsche Arzneibuch 2006 (DAB 2006), German Federal Institute for Drugs and Medicines, Bonn, 2006. Eccleston GM. Functions of mixed emulsifiers and emulsifying waxes in dermatological lotions and creams.
Dermatological properties of alkyl polyglucosides. In: Hill K, von Rybinski W, Stoll G, eds. Alkyl Polyglycosides – Technology, Properties and Applications. Weinheim: VCH, 1997. Mehling A, Hensen H. Comparative studies on the irritation potential of surfactants. Exog Dermatol 2004; 191–200. Mehling A, Kleber M, Hensen H. Comparative studies on the ocular and dermal irritation potential of surfactants. Food Chem Toxicol 2007; 45: 747–58.
It seems reasonable to assume that the glucopyranoside part of the APG surfactant is directed to this portion of interlamellarly fixed water, with monosaccharide hydroxyl groups capable of hydration and swelling. Alkyl chains of surfactants are situated between the alkyl chains of fatty alcohols, in their extended forms, producing the lipophilic bilayer. Thus, the gel phase consists of two parts – hydrophilic and lipophilic gels. This type of structural organization is mostly seen in binary systems.
Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems by Ivana Pantelic