Read e-book online Alzheimer's disease : life course perspectives on risk PDF

By Amy Borenstein, James Mortimer

ISBN-10: 0124171540

ISBN-13: 9780124171541

ISBN-10: 0128045388

ISBN-13: 9780128045381

Alzheimer's affliction: Lifecourse views on possibility relief summarizes the turning out to be physique of information at the distribution and factors of Alzheimer’s ailment (AD) in human populations, delivering the reader with wisdom on how we outline the illness and what its probability and protecting components are within the context of a life-course strategy.

At the belief of the e-book, the reader will comprehend why Alzheimer’s illness most probably starts off at perception, then progresses via early-life and grownup threat elements that finally impression the stability among pathologic insults within the mind and the facility of the mind to change affliction indicators. unlike edited volumes that could have little team spirit, this publication makes a speciality of an built-in life-course method of the epidemiology of dementia, specifically, Alzheimer’s sickness.

  • Reviews the present technology surrounding Alzheimer’s disease
  • Provides a primer of foundational wisdom at the disease's epidemiology and biostatistics
  • Utilizes a life-course procedure, delivering a singular and built-in view of the evolution of this disease from genes to mind reserve
  • Uses the ‘threshold model’—a conception first defined through Dr. Mortimer and largely accredited today—which contains the belief of chance components for the pathology and expression of the sickness
  • Proposes that enhancing mind well-being via modifiable behaviors can hold up illness onset until eventually a later age
  • Examines the way forward for prevention of Alzheimer’s disorder, a subject matter of serious present interest

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Extra resources for Alzheimer's disease : life course perspectives on risk reduction

Example text

Additionally, the records must be detailed and complete enough to produce diagnoses that are valid and that minimize missing data. One problem with passive ascertainment is that the case must be severe enough to result in the individual seeking medical attention. Therefore, this method is relatively insensitive for milder cases of dementia, AD, or MCI. In the Mayo Clinic Study on Aging, a study was undertaken to determine the sensitivity of the passive method using an in-person evaluation as the gold standard to detect prevalent dementia.

Because DSM-V criteria have not been used in epidemiologic studies to date, we will not consider its definitions. , cerebrovascular disease, Parkinson’s disease, Huntington’s disease, subdural hematoma, normal-pressure hydrocephalus, or brain tumor), (3) there are no systemic conditions that can cause dementia, for example, urinary tract infection, (4) the deficits are not caused by substance-induced conditions, and (5) the deficits are not caused by another Axis I disorder, such as major depressive disorder or schizophrenia.

Clinical criteria define a phenotype, and the accuracy of the clinical diagnosis can be judged using the neuropathologic diagnosis as the gold standard. When a clinical diagnosis is made, how well does it predict the actual neuropathologic diagnosis? This requires the quantification of the positive predictive value (PPV), the probability of having the neuropathologic diagnosis given a clinical diagnosis. , 1995), but varies depending on where the diagnosis is made (a highly specialized dementia clinic will have higher figures), what criteria are used, and how old the person is.

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Alzheimer's disease : life course perspectives on risk reduction by Amy Borenstein, James Mortimer


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